Trace determination of parabens in cosmetics and personal care products using fabric‐phase sorptive extraction and high‐performance liquid chromatography with UV detection

A simple, fast, and sensitive analytical protocol using fabric‐phase sorptive extraction followed by high performance liquid chromatography with ultraviolet detection has been developed and validated for the extraction of five parabens including methylparaben, ethylparaben, propylparaben, butylparaben, and benzylparaben. In the present work, sol‐gel polyethylene glycol coated fabric‐phase sorptive extraction membrane is used for the preconcentration of parabens (polar) from complex matrices. The use of fabric‐phase sorptive extraction membrane provides a high surface area which offers high sorbent loading, shortened equilibrium time, and overall decrease in the sample preparation time. Various factors affecting the performance of fabric‐phase sorptive extraction, including extraction time, eluting solvent, elution time, and pH of the sample matrix, were optimized. Separation was performed using a mobile phase consisting of water:acetonitrile (63:37; v/v) at an isocratic elution mode at a flow rate of 0.9 mL/min with wavelength at 254 nm. The calibration curves of the target analytes were prepared with good correlation coefficient values (r² > 0.9955). The limit of detection values range from 0.252 to 0.580 ng/mL. Finally, the method was successfully applied to various cosmetics and personal care product samples such as rose water, deodorant, hair serum, and cream with extraction recoveries ranged between 88 and 122% with relative standard deviation <5%.     

SOFA评分联合超声对脓毒症合并AKI患者的预后价值分析

本文主要探究SOFA评分联合超声对脓毒症合并急性肾损伤(AKI)患者的预后价值。选取2017年1月~2019年1月本院脓毒症合并AKI患者50例作为观察组,并分为AKI 1、2、3期,将同期入院的50例脓毒症患者作为对照组,两组患者均采用SOFA评分联合超声进行预后评估。结果发现,观察组PDU评分低于对照组(P<0.05),RI值、SOFA评分高于对照组(P<0.05);不同分期的3组间的PDU评分、SOFA评分不同,随着AKI分期的增加,PDU评分降低、SOFA评分增加(P<0.05),但3组间的RI值并无不同(P>0.05);50例脓毒症合并AKI患者发生院内死亡率为44.00%。经单因素分析发现,年龄、机械通气时间、ICU住院时间、AKI分期、脓毒症休克、SOFA评分、PDU评分为影响患者预后不佳的因素(P<0.05);AKI3期、发生脓毒性休克、SOFA评分、PDU评分是脓毒症合并AKI患者预后不佳的独立因素(P<0.05),ROC曲线下面积(AUC)越大,对预后的预测效能越好,当AUC>70.00%时具有临床价值。两者联合显著高于单独应用SOFA评分(AUC=74.28%)或PDU评分(P<0.001)。上述结果说明,脓毒症合并AKI患者采用SOFA评分联合超声用于评估患者的预后,优于单独采用SOFA评分或超声,两者联合的预测价值更大。     

Organophosphate esters by GC–MS: An optimized method for aquatic risk assessment

Organophosphate esters used as flame retardants and plasticizers are ubiquitous contaminants in surface waters. Many studies indicate that these compounds are neurotoxicants, endocrine disruptors, and may affect reproduction and development of aquatic organisms. Thus, analytical methods that allow accurate quantification of these contaminants at environmentally relevant concentrations are desirable for risk assessment studies. In this study, a method based on solid phase extraction and gas chromatography coupled to mass spectrometry was developed for determination of organophosphate esters in river water extracts. Multivariate optimization was used to determine the best conditions for injection of larger volumes of sample in a Programmable Temperature Vaporization inlet. Furthermore, the matrix effect on the instrumental response was evaluated and compensated by association of extraction‐blank‐matched calibration and isotopically labeled focus standards. The method quantification limits ranged from 0.009 to 0.11 µg/L, staying below the predicted non‐effect concentration for the aquatic compartment for all analytes, which is a requisite for using in risk assessment studies. The method was applied to freshwater samples collected in rivers from the Sao Paulo State, Brazil, and eight out of the ten target organophosphate esters were quantified, being tris(2‐chloroisopropyl) phosphate and tris(phenyl) phosphate the most frequently detected compounds.     

深共熔溶剂-高效液相色谱联用提取测定环境水样中的3种药品和个人护理品

建立了深共熔溶剂-高效液相色谱联用提取测定环境水样中3种药品和个人护理品(PPCPs)的方法。通过优化前处理条件,3种PPCPs(氯霉素、氯苯甘醚和萘普生)利用氯化胆碱-乙二醇深共熔溶剂为提取剂,经超声功率120 W下超声波提取5 min,离心转速9000 r/min下离心10 min富集提取。采用外标法定量分析,在5.0~200.0 mg/L范围内线性关系良好,相关系数r≥0.9998。3种环境水样中PPCPs的回收率为81.4%~94.8%,相对标准偏差分别为1.5%,0.4%和0.3%。氯霉素、氯苯甘醚和萘普生的方法检出限(LODs)分别为0.9,3.3,1.6 mg/L,定量限(LOQs)分别为3.1,12.2,5.0 mg/L。方法能够满足环境水样中3种PPCPs的检测需求。     

台风灾害快速评估信息系统设计与开发

以台风综合强度指数和台风风场模型的理论为基础,采用C#＋ArcEngine技术进行二次开发,设计并开发了一套以台风综合强度和影响范围评估为主要功能的台风灾害快速评估系统.提出了一种更全面的台风致灾因子危险性评估方法,以期为台风灾害风险评估提供基础.     

基于MEMS惯性技术的鞋式个人导航系统

研究了低精度鞋式个人惯性导航系统的导航修正算法.该系统由低精度MEMS惯性IMU单元组成,固联在步行者的鞋上.导航算法在传统捷联惯性导航算法基础上,引入了零速修正技术,根据人行走时脚部运动的加速度统计特性,设计了一种比力模值+滑动方差检测算法,用以检测行走过程中的静止时间段.然后通过设计的改良卡尔曼滤波器在静止时间段内滤波估计导航姿态、速度和位置的计算误差,通过反馈校正可以提高原系统的导航精度.最后通过两组MEMS实物实验验证了导航修正算法的有效性和可行性,并指出了进一步的研究方向.     

Gumbel分布的简单贝叶斯估计

在实际应用中,两参数Gumbel分布的贝叶斯估计往往需要预先知道Gumbel参数的二维联合先验分布。由于获取先验分布的主观性和统计推断的复杂性,目前有关Gumbel分布贝叶斯估计理论及其性质的讨论还比较少,更不要说获得较为简单的Gumbel分布的贝叶斯估计。本文基于Kaminskiy和Vasiliy提出的简单贝叶斯估计过程,利用可靠度函数估计的区间形式表示先验信息,从而得到两个参数Gumbel分布的简单贝叶斯估计。基于此先验信息,该估计过程构造了Gumbel参数的连续联合先验分布,给出了在给定任意时点的可靠度(或累积密度)及其标准差的后验估计,为可靠性与风险评估中简单快速的使用贝叶斯估计刻画极端事件提供了可能.     

Incorporating ergonomic risks into assembly line balancing

In manufacturing, control of ergonomic risks at manual workplaces is a necessity commanded by legislation, care for health of workers and economic considerations. Methods for estimating ergonomic risks of workplaces are integrated into production routines at most firms that use the assembly-type of production. Assembly line re-balancing, i.e., re-assignment of tasks to workers, is an effective and, in case that no additional workstations are required, inexpensive method to reduce ergonomic risks. In our article, we show that even though most ergonomic risk estimation methods involve nonlinear functions, they can be integrated into assembly line balancing techniques at low additional computational cost. Our computational experiments indicate that re-balancing often leads to a substantial mitigation of ergonomic risks.     

Measurement of Returns to Scale and Damages to Scale for DEA-based operational and environmental assessment: How to manage desirable (good) and undesirable (bad) outputs?

Environmental assessment is increasingly important in preventing various types of pollutions. Data Envelopment Analysis (DEA) has been long used as an operational performance measure, but we have insufficiently explored the use of DEA for environmental assessment. This study explores a new use of DEA for the environmental assessment in which outputs are classified into desirable (good) and undesirable (bad) outputs. Such an output separation is important in the DEA-based environmental assessment. This study extends the use of DEA to the measurement of both Returns to Scale (RTS) for desirable outputs and Damages to Scale (DTS) for undesirable outputs. A Range-Adjusted Measure (RAM) is used as a DEA model for this study because the non-radial model can easily combine the two types of outputs in a unified treatment. All the mathematical features regarding the RAM-based RTS/DTS measurement are first discussed from the operational and environmental performance in a separate treatment. Then, this study combines the two performance measures as a unified measure. The RAM-based RTS/DTS is mathematically explored from the unified measure for operational and environmental performance.     

企业协同知识创新的风险识别与评价

协同知识创新是企业降低创新成本,提高创新能力的重要手段.由于企业知识创新具有高度的不确定性和不可预测性,因此,有效地利用企业协同优势,有针对性地降低协同知识创新的风险,是协同知识创新活动得以顺利开展的重要条件.影响协同知识创新的内外因素有很多,利用粗糙集理论对这些因素进行简约,消除冗余因素,得到在协同知识创新中的核心因素;确定约简集因素权重,判断协同知识创新的风险程度,为协同知识创新的决策提供依据.